Anion exchanger 2 mediates the action of arsenic trioxide
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چکیده
منابع مشابه
Mechanisms of action of arsenic trioxide.
Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and relapsed patients with acute promyelocytic leukemia (APL). As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression. These successes have prompted investigations to elucidate the mechanisms of action underlying these clinical responses. Substantial data sh...
متن کاملArsenic trioxide
At an acute ingestion of arsenic trioxide, nausea, vomiting, diarrhea, and abdominal pain are early symptoms occurring within 30 min to several hours. Primary target organ is the gastrointestinal tract (GIТ), where hemorrhagic gastroenteritis can occur in serious cases. Among cardiovascular symptoms are tachycardia, ventricular fibrillation, and heart failure described. Neurological symptoms ca...
متن کاملGolgi - Associated Anion Exchanger , Ae 2
Anion exchanger 2 (AE2) is a member of the anion exchanger gene family, which includes three additional members, AE1, AE3, and AE4. They are also known as Na+-independent Cl/HCO3 exchangers, and their major function is to regulate intracellular pH and chloride concentration. All four isoforms have several N-terminally truncated variants that are often expressed cell type specifically. Red blood...
متن کاملCardiac toxicity of arsenic trioxide
tion of Karpas 299 cells with immobilized antibodies to CD30 was found to potently induce cell death, whereas in the same experiment the addition of these antibodies in their soluble form did not induce cell death and actually slightly enhanced viability (Figure 1). Also noteworthy is the fact that, in the earlier report by Gruss et al4 in which the cytotoxic effects of M44 and M67 were origina...
متن کاملAntitumor activity of arsenic trioxide on retinoblastoma: cell differentiation and apoptosis depending on arsenic trioxide concentration.
PURPOSE Arsenic trioxide (ATO) targets multiple pathways in malignant cells, resulting in the promotion of differentiation or in the induction of apoptosis. The antitumor activity of ATO on retinoblastoma was investigated. METHODS Human retinoblastoma cells were incubated with various ATO concentrations. The antiproliferative effect of ATO was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-dip...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2006
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.2006.06224.x